Bisphosphonates and Your Dental Health
December 22nd, 2009Bisphosphonates and Your Dental Health
Question:
There’s a lot of talk about Bisphosphonates, which are used for various medical conditions. Can you explain why this medication is used and how it might affect my dental condition?
Answer:
Bisphosphonate drugs come in oral (pill) or intravenous (IV) form. Oral Bisphosphonates are used mainly to treat osteoporosis and osteopenia. The oral (pill) forms are commonly known as Fosomax, Actonel and Boniva. Intravenous bisphosphonates are primarily used to prevent cancer from spreading to the bones or in cases of multiple myeloma. These IV forms include Aredia, Zometa and Reclast.
Although it is rare, these drugs can damage the bones of the upper and lower jaws. Patients taking these drugs who have a tooth extracted or surgery involving the jaw, may experience death of the bone of the jaw, or Bisphosphonate-related osteonecrosis of the jaw (BRONJ). In very rare instances, BRONJ can occur spontaneously, without a cause.
Question:
It seems like oral bisphosphonates for treating osteoporosis are creating somewhat of a road block for certain dental surgical procedures. Should these patients consider an increase in preventive care, such as going for checkups and cleanings three or four times a year instead of the usual two times?
Answer:
Yes, preventative dental care should definitely be increased in patients taking bisphosphonate medications. If a cavity can be treated when it is a small lesion, only a filling is required, while larger ones may need root canals and crowns. Any of these procedures will often prevent the need for more complex dental extractions and surgeries. That is why having regular dental exams along with cleanings is the best way to prevent BRONJ.
Question:
What is the risk of BRONJ occurring? Can it happen if a patient cuts their gums due to everyday events like tooth brushing or eating a hard food, such as a taco chip?
Answer:
The incidence of oral side effects from the oral bisphosphonate medications is really very low. Studies show a 1 in 10,000-100,000 risk of occurrence after tooth extraction. Surgery involving the jaw, such as an implant or bony periodontal surgery, could also increase the risk. However, in our practice, we have not seen a single case occur from a tooth extraction. It is even less likely for BRONJ to result from minor cuts caused by brushing or eating. Patients needn’t be concerned about BRONJ resulting from minor trauma.
Question:
What precautions are taken for patients on a bisphosphonate drug who need a tooth extraction or dental implant? Are any extra precautions needed for more routine dental care, such as cleanings or fillings or even root canals?
Answer:
Patients on oral bisphosphonate medications for three years or more, or who have taken even one dose of intravenous bisphosphonate, may require a blood test to determine the risk for BRONJ. Patients whose results indicate they are at high risk for BRONJ will be asked to discontinue the bisphosphonate medication three months pre- and post-extraction, with approval from their prescribing doctor. If patients are at severe risk, dental extractions are avoided and the tooth is treated with root canal therapy and removal of the crown.
No special precautions are needed for routine care, including cleanings, fillings, crowns and other general dental care.
Question:
What exactly is the test given to determine risk of BRONJ? How does the test predict a patient’s risk?
Answer:
It is a morning blood test, taken after a patient has not eaten for eight hours.
Those with blood values that indicate a low risk may continue to take their oral medications; patients with moderate to severe risk disease are asked to discontinue the medication for three months before the extraction or surgery and three months afterward.
Question:
How is BRONJ treated, and what is the general prognosis?
Answer:
BRONJ is not an infection, but a process by which bone is destroyed. BRONJ is treated first by discontinuing the bisphosphonate medication, with approval from the prescribing doctor. Antibiotics are used to help minimize the amount of bacteria in the mouth and allow the bone to heal itself. BRONJ is considered successfully treated when the signs and clinical symptoms are gone–pain is resolved, there is no exposed bone in the mouth and the gums are completely healed. In rare cases, the affected bone must be surgically removed, which may result in a serious jaw defect.
Dr. Barry Cherny received his Bachelor’s degree in Biology from the University of Illinois, and a Bachelor’s degree in Dentistry and Doctor of Dental Surgery from the University of Illinois. His internship and residency in Oral and Maxillofacial Surgery were completed at the University of Illinois Hospital and Clinics, Michael Reese Medical Center, West Side Veterans Administration Hospital and Cook County Hospital. He is a Diplomat of the American Board of Oral and Maxillofacial Surgery, a Fellow of the American Association of Oral and Maxillofacial Surgeons and a Fellow of the American College of Oral and Maxillofacial Surgery. He is also a member of the Illinois Society of Oral and Maxillofacial Surgeons and the Chicago Society of Oral and Maxillofacial Surgeons.
Dr. Cherny is in private practice with his partners, Dr. Bruce Hochstadter, Dr. Richard Isaacson, Dr. Leo Dumanis, Dr. Nick Katris and Dr. Michelle Pashley. They practice the full scope of Oral and Maxillofacial Surgery at their three office locations:
Westfield / Old Orchard Professional Building
64 Old Orchard Rd, Suite 229
Skokie, IL 60077
847-675-6868
444 N. Northwest Highway, Suite 325
Park Ridge, IL 60068
847-296-6100
600 W. Lake Cook Rd, Suite 101
Buffalo Grove, IL 60089
847-229-1300